Biologie celulară

Celula canceroasă

Factorii de inducţie ai celulei canceroase

Celulele transformate sau tumorale apar în urma acţiunii unor factori cu incidenţă primară cum ar fi substanţe chimice, acţiunea cancerogenă a agenţilor fizici şi acţiunea de transformare cancerogenă a virusurilor. Aceşti factori acţionează la nivel molecular, mai ales asupra acizilor nucleici (ADN şi ARN), de unde şi noţiunea modernă de ’’cancer — boală moleculară”.

Read more ...

Organitele citoplasmatice

Ribozomii (granulele lui Palade)

Etimologie: ribos gr.= granulă, soma gr.= corp (în trad liberă - corpi granuloşi)

Ribozomii sunt organite citoplasmatice prezente atât în celulele procariote cât şi în cele eucariote, cu puţine excepţii, ca de exemplu eritrocitele mature ale mamiferelor. Å

Read more ...

Recunoaşterea celulară, îmbătrânirea şi moartea celulelor

Recunoaşterea celulară

Se consideră că apariţia organismelor multicelulare a fost marcată de asocierea organismelor unicelulare în colonii

Dacă în urma fiecărei diviziuni celulele-fiice rămân asociate, ele pot forma o „colonie’".

Read more ...

Celula

Definiție: Celula este unitatea principală structurală, funcțională și genetică a organismelor vii.

La baza alcătuirii organismului uman, ca de altfel și al tuturor viețuitoarelor, se află celula. Întregul organism uman este alcătuit din celule. Celulele pot exista singure (exemplu: globulele albe din sânge) sau grupate, formând țesuturi (exemplu: țesutul nervos, alcătuit prin gruparea neuronilor).

Read more ...

Mixul de marketing si pachetul complex de produse si servicii

De la aparitia sa si pana în prezent, marketingul a fost abordat sub diferite aspecte, de la teorii de piata la elemente constitutive, toate s-au axat pe cele patru elemente ale mixului de marketing: produs, pret, plasament si promovare, în jurul lor dezvoltandu-se politicile specifice, corelatiile dintre acestea, metodele si tehnicile de investigare, textele experimentale, studiile de motivatii.

Read more ...

Mixul de marketing

Dezvoltarea conceptului de "mixul de marketing" poate fi considerată una dintre ideile dominante în practica şi teoria marketingului modern.

Din punct de vedere conceptual, termenul de "mixul de marketing" a fost dezvoltat la bază de către profesorul Neil H. Borden pentru a descrie combinaţia potrivită, pentru un set particular de circumstanţe, a 4 elemente cheie, care constituie partea principală a oricărui program de marketing dintr-o firmă (Wilmshurst şi Mackay, 2002).

Read more ...

Evidenţa arendei finanţate

În cazul arendei finanţate bunurile se reflectă în Bilanţul contabil al arendaşului, care calculează şi uzura unor astfel de bunuri atît în contabilitatea financiară, cît şi în scopuri fiscale. Arendatorul reflectă transmiterea bunurilor în arendă finanţată ca ieşire a acestora.

Read more ...

Conceptul de marketing direct

Definirea marketingului direct

În ultimele decenii, la nivel mondial, marketingul direct a cunoscut o dezvoltare considerabila, depasind cu mult limitele începuturilor sale, adica comertul traditional prin posta, apeland acum la o multitudine de noi tehnologii si de tehnici de construire a relatiei cu clientul precum si la evaluarea performantelor de marketing.

Astfel, asistam în prezent la o renastere a comertului traditional prin posta sub forma comertului electronic prin Internet, ai carui comercianti electronici utilizeaza tehnici de marketing si instrumente promotionale care au fost verificate si folosite timp de multe zeci de ani. Aceste instrumente si tehnici au fost adaptate si s-au dovedit mult mai viabile decat formele initiale de marketing direct.

Read more ...

Ce este Marketingul

Marketingul reprezintă una din marile „descoperiri” ale acestui secol, o ştiinţă ce a fost dezvoltată şi este utilizată (sau cel puţin aşa ne place să credem) în scopul unei mai armonioase dezvoltări economico-sociale a societăţii omeneşti. Totuşi, nu trebuie să considerăm că ştiinţa marketingului a apărut brusc, undeva la începutul secolului XX.

Read more ...

Esenţa operaţiunilor de plăţi şi decontări în cadrul băncii comerciale

Esenţa şi formarea relaţiei bancă-client

Totalitatea operaţiunilor pe care le efectuează banca în folosul clienţilor pot fi clasificate în 3 categorii având la bază funcţiile principale ale băncii:

  • Serviciile de finanţare a necesităţilor de resurse ale clienţilor – operaţiuni de creditare;
  • Serviciile de acumulare a resurselor prin acordarea clienţilor a posibilităţilor de economisire a excedentelor de lichidităţi – operaţiuni de depozitare;
  • Serviciile de transfer de fonduri în interesul clienţilor sau interes propriu.
Read more ...

Pomicultura

Pomicultura este ramura agriculturii care se ocupă cu studiul şi tehnica culturii pomilor şi arbuştilor fructiferi.

Pomicultura are o deosebită însemnătate pentru economia naţională , datorită produselor de calitate ce se obţin, ele fiind solicitate de către populaţie şi industrie într-un sortiment diversificat. Fructele aduc un aport esenţial în alimentaţia raţională atât prin conţinutul lor în substanţe nutritive şi energetice şi în special prin influenţa favorabilă pe care o au asupra funcţiilor organismului omenesc.

Read more ...

Consumul şi consumatorul

Studiul comportamentului agenţilor economici în viaţa economică, în condiţiile în care nevoile sunt nelimitate, iar resursele economice necesare producerii de bunuri au un caracter limitat, constituie unul din domeniile importante de abordare a ştiinţei economice.

Read more ...

Producţia şI producătorul

Resursele economice disponibile sunt valorificabile în măsura în care ele sunt atrase şi utilizate în activitatea economică. Ele apar ca fluxuri şi se transformă în factori de producţie. O delimitare conceptuală între cele două noţiuni (resurse, factori de producţie) se impune, deşi, în sine, termenii sunt utilizaţi ca fiind sinonimi:

Read more ...

Accizele

Accizele — caracteristica generală

Accizele reprezintă taxele de consumaţie pe produs. De obicei ele sunt aşezate asupra produselor cu cerere neelastică. Tipurile de produse cu aşa o cerere sunt foarte diverse şi diferă de la o ţară la alta. În RM sunt supuse accizului o gamă largă de produse şi mărfuri: băuturile spirtoase tari, vinurile, tutunul, metalele preţioase, blănurile de lux, parfumeria, audio şi video aparatura, autoturismele ş.a.

Read more ...

Impozit pe venit, particularităţile impunerii veniturilor agenţilor economici

Noţiunile principale privind impozitul pe venitul agenţilor economici.

Subiecţii şi obiectul impunerii

Subiecţi ai impunerii fiscale se consideră:

  • Agenţii economici-rezidenţi ce obţin venituri din Republica Moldova şi din străinătate;
  • Agenţii economici-nerezidenţi ce obţin venituri din Republica Moldova. (art. 13).

La impozitul pe venit pentru persoane juridice obiectul impunerii fiscale îl constituie venitul brut, care cuprinde: (art. 14)

Read more ...

Impozitul pe venit

Impozit pe venit – noţiuni generale

Subiecţii impozitului pe venit sînt persoanele fizice rezidente şi nerezidente care obţin venituri din categoria celor impozabile. Persoana fizică este considerata:

  • cetăţean al Republicii Moldova
  • cetăţean străin
  • apatrid
  • întreprindere cu statut de persoană fizică (întreprinderi individuale(I.I.) şi gospodăriile ţărăneşti (G.T.).
Read more ...

Evidenţa cheltuielilor privind impozitul pe venit

Cheltuielile privind impozitul pe venit includ plăţile impozitului pe venit efectuate în decursul (sub formă de avansuri) şi la sfîrşitul anului de gestiune. Pentru evidenţa acestor cheltuieli este destinat contul 731 „Cheltuieli (economii) privind impozitul pe venit”.

În condiţiile aplicării cotei „zero” la impozitul pe venit contul 731 „Cheltuieli (economii) privind impozitul pe venit” nu se aplică.

Read more ...

Întreprinderea ca celulă de bază a economiei

Definirea întreprinderii şi caracteristicile ei

Întreprinderea este o unitate instituţională de bază a economiei naţionale care se caracterizează printr-un gen specific de activitate, funcţionalitate, organizare tehnologică, prin capacitatea de a produce bunuri, de a se conduce şi gestiona raţional, precum şi prin autonomia sa financiară.

Read more ...

Planificarea şi organizarea remunerării muncii în cadrul întreprinderii

Planificarea fondului de salarii

Fondul de salarii pentru orice subdiviziune structurală a întreprinderii se divizează în fond orar, zilnic, lunar, trimestrial şi anual.

Fondul de salarii orar constă din retribuţia pentru timpul lucrat/volumul de producţie fabricat, care constă din salariul tarifar, primele în funcţie de formele de salarizare (acord sau regie), plăţi cu caracter compensaţional, adaosuri pentru timpul de lucru supraprogram şi în orele de noapte, conducerea echipelor, instruirea ucenicilor.

Read more ...

Conservarea produselor alimentare

Prin conservare se realizează stabilizarea relativă a proprietăţilor unui produs. În domeniul produselor alimentare, a conserva înseamnă a stabili anumite proprietăţi ale unui produs în faza prelucrării. Conservarea asigură creşterea stabilităţii produselor alimentare.

Read more ...

Supply Chain Management

Purchasing strategies and Supplier Selection

Strategic Role of Purchasing

Purchasing function has a strategically indispensable role to play in supply chain management. It covers the sourcing end of supply chain management interfacing with the delivery end of the suppliers.

The classical definition of purchasing is: to obtain materials and/or services of the right quality in the right quantity from the right source, deliver them to the right place at the right price.

Read more ...

Buyer behaviour

In this lesson, we will introduce you to the process through which the ultimate buyer makes purchase decisions. After you work out this lesson, you should be able to:

  • Identify what stimulates a consumer to consider buying
  • Describe the buyer’s decision-making process and the several factors which influence this decision
  • Understand the response of the buyer to the marketing and other stimuli
Read more ...

Supply Chain Design and Analysis: Models and Methods

For years, researchers and practitioners have primarily investigated the various processes within manufacturing supply chains individually. Recently, however, there has been increasing attention placed on the performance, design, and analysis of the supply chain as a whole.

Thisattention is largely a result of the rising costs of manufacturing, the shrinking resources of manufacturing bases, shortened product life cycles, the leveling of the playing field within manufacturing, and the globalization of market economies.

Read more ...

The legacy of the discipline of geopolitics

The disciplines of geoeconomic and geopolitics are closely intertwined. The discipline of geopolitics has a burden full past and can only progress through self-critique: that is through criticism of the discipline itself. For instance, it must be made clear what in geopolitics is objective and what is normative. So far this criticism has come mostly from outside, from its opponents, whether they represent critical geopolitics, political geography, or mainstream political science.

Read more ...

Information Processing

Accounts, Debits, and Credits

The previous chapter showed how transactions caused financial statement amounts to change. “Before” and “after” examples, etc. was used to develop the illustrations. Imagine if a real business tried to keep up with its affairs this way! Perhaps a giant chalk board could be set up in the accounting department.

As transactions occurred, they would be called in to the department and the chalk board would be updated. Chaos would quickly rule. Even if the business could manage to figure out what its financial statements were supposed to contain, it probably could not systematically describe the transactions that produced those results. Obviously, a system is needed.

Read more ...

Introduction to Marketing Mix

In this lesson, we will introduce you to the activities that comprise a firm’s marketing program. These activities are popularly referred to as the 4 Ps – product, price, place and promotion. After you work out this lesson, you should be able to:

  • Understand the major product decisions in marketing planning
  • Know the pricing objectives and the factors that influence the pricing decisions
  • Appreciate the role of marketing channels and understand the important channel decisions to be taken
  • Comprehend the Promotion Mix of marketing and the different elements in the promotion mix
  • Learn how the 4 Ps combine to create effective marketing programs
Read more ...

Market Segmentation, Targeting and Positioning

In this lesson, we will introduce you to the activities, viz., segmentation, targeting and positioning, that are collectively referred to as marketing strategy. After you work out this lesson, you should be able to:

  • Segment the markets based on several segmentation variables
  • Target a segment by identifying the fit between segment profitability and organizational capability
  • Position your product/service so that it occupies a distinct and valued place in the target customers’ minds
Read more ...

Internal Marketing versus External Marketing

Abstract: International marketing orientation requires modern concepts of economic activities in accordance with the requirements and specific foreign markets (national, multinational, global) in order to meet their current and future needs with maximum efficiency. The need for knowledge of international marketing occurs when we have to realize, to sell and promote goods and services to consumers and users in other countries.

Read more ...

Marketing Environment

In this lesson, we will introduce you to the forces that define marketing’s external environment. After you work out this lesson, you should be able to:

  • Identify, analyze and monitor external forces and assess their potential impacts on the firm’s goods and services
  • Understand how marketers formulate their strategy within the frame of reference provided by the forces in the external environment

In this lesson, we will discuss the following:

Marketing Process

Objectives of Marketing Process

In this lesson, we will introduce you to the activities that makeup the marketing process. After you work out this lesson, you should be able to:

  • Identify the parts of the marketing process
  • Understand the relationships among the parts of the marketing process
  • Explain how the marketing process creates, captures and sustains value for the customer
Read more ...

Marketing Concepts

Objectives of marketing concepts

In this lesson, we will introduce you to the conceptual ideas that makeup the marketing function of a business. After you work out this lesson, you should be able to:

  • List out the concepts of marketing
  • Understand how these concepts are interconnected
  • Explain how marketing is changing in a connected world
Read more ...

Introduction to Marketing

In this lesson, we will introduce you to the business function of marketing. After you work out this lesson, you should be able to:

  • Define marketing and the utility (value) it creates for the customer
  • Trace the origin of marketing and explain how it has evolved
  • Describe the elements of a marketing strategy
  • Understand the scope of marketing
Read more ...

Definition and trends within Purchasing Management

The aim of this chapter is to provide the reader with an introduction to Purchasing Management in order to fully appreciate the book. The chapter presents the book's definition of Purchasing Management as well as briefly presenting the potential benefits with working at a strategic level with purchasing activities for a corporation.

Furthermore trends and historical developments within the area of Purchasing Management will be presented.

Read more ...

Purchasing Organization

The structure of the purchasing department is especially important in external and internal networks. The organizational model must facilitate activities in different strategic levels as well as cope with changes in external environment. By adjusting formalization and centralization levels, the organization can be positioned to best support the organization.

However, no universal solution exists, as the right structure is highly company specific and dynamic over time. Therefore, this is one of the major challenges that Purchasing Management confronts within business networks.

Read more ...

Purchasing management and internal collaboration

Strategic purchasing is most often associated with external relations. However, purchasing integration and internal collaboration are the enablers of every corporate strategy. The aim of this chapter is to explain the connections between purchasing and the company's competitive priorities as well as emphasize the need for interdepartmental collaboration.

Read more ...

We begin our study of microeconomics by looking at a market with many buyers and sellers, i.e. a market where there is a large amount of competition. We will study such a market in more depth in Perfect Competition, as well as other market types, but starting here makes it easy to get a feel for how the subject works.

Demand

The Demand Curve

The demand curve shows what quantities of a good buyers are willing to buy at different prices. Note the expression “are willing.” It is not about how much they actually buy, but about how much they would want to buy if a certain price was offered. A demand curve is only valid if all other relevant factors are held constant (ceteris paribus: with other things the same). The most important other factors that can affect demand are:

The buyers’ income.

 

Prices and price changes on other goods. We will make a distinction between complementary goods and substitute goods. An example of complementary goods is right and left shoes. If the price of right shoes rises then the demand for right shoes will typically decrease. However, the demand for left shoes will also typically decrease. Consequently, the demand for left shoes partly depends on the price of another good: right shoes.

Substitute goods work in the opposite way. An example could be blue and green pens: If one cannot use blue, one can often use green instead. If the price of green pens rises, the demand for green pens typically decreases. However, if the price of blue pens is unchanged one can use these instead of the green ones, and then the demand for blue pens increases. Consequently, the demand for blue pens depends on the price of another good: green pens.

Note that for substitute goods, a rise in the price of the other good leads to an increase in the demand for the good we are analyzing, whereas for complementary goods it is the other way around; a rise in the price of the other good leads to a decrease in the demand for the good analyzed.

Preferences. What consumers demand is largely a matter of taste. If there is a change in taste, there is usually also a change in demand. Taste can change for many different, underlying, reasons. For example, changes in moral perception or in fashion.

If these factors are held constant, then the demand curve is valid and it usually slopes downwards. In other words, the lower the price is the higher is the demand, and vice versa. Demand is defined for a certain period. One can for example think of it as defined over a month, corresponding to a monthly salary. When drawing a demand curve in a diagram, the quantity demanded is on the X-axis and the price is on the Y-axis. This is slightly odd, since we often think of the quantity demanded as a function of the price, not the other way around. There are historical reasons for drawing it this way.

When do We Move along the Demand Curve, and When Does It Shift?

The relation between price and quantity that is described by the demand curve is valid only if it is the price of the good itself that changes. Look at Figure 2.1 and the demand curve D1. If, in the beginning, the price is p1, then the quantity demanded is Q1 (point A). If the price of the good falls to p2, then the quantity demanded changes to Q2 (point B). We, consequently, move along the demand curve when the price of the good changes.

The Demand Curve

Figure 2.1: The Demand Curve

If, instead, something else changes (e.g. income, the prices of other goods,consumer preferences, or anything that affects the demand on the good), then the demand curve shifts. Assume again that the price is p1 so that the quantity demanded is Q1 (point A). If the consumer’s income increases, she can buy more of the good than she could before. Consequently, the whole demand curve shifts from D1 to D2. If the price is still p1, the quantity demanded increases to Q3 (point C).

Supply

The Supply Curve

The producer counterpart to the demand curve is the supply curve. It shows how large quantities the producers are willing to sell at different prices, given that other factors that can affects supply are held constant. The supply curve is typically upward sloping or horizontal (but it could also be downward sloping).

The demand curve is also valid over a certain period. Later, we will distinguish between two time periods: short and long horizons. The most important factors, beside the price, that affect supply are:

  • Factor prices , i.e. wages, prices of machines and compensation to owners and lenders. In other words, changes in the cost of production.
  • Laws and regulations that apply to the production.
  • Prices of other goods the firm produces or could potentially produce. Perhaps the producer is producing blue and green pens. If the price of green pens rises, she is likely to shift over resources (workers and machines) to that production and there is less left with which to produce blue pens. Consequently, the supply of blue pens decreases, even though the price of blue pens is unchanged.

The Supply Curve

Figure 2.2: The Supply Curve

The supply curve behaves in a way that is similar to that of the demand curve. Look at Figure 2.2 and the supply curve S1. If the price isp1, then the producers are willing to sell the quantity Q1 (point A). If the price of the good falls to p2, we move along S1 to point B, where the quantity is Q2. If, instead, some other factor changes, e.g. if wages increase so that it becomes more expensive to produce the good, the whole supply curve shifts. For instance from S1 to S2. If the price is still p1, then the quantity supplied changes from Q1 to Q3 (point C).

Equilibrium

A market is in equilibrium when both of these conditions are fulfilled:

  • No agent wants to change her decision or strategy.
  • The decisions of all agents are compatible with each other, so that they can all be carried out simultaneously.

If we join the supply and demand curves in one diagram, we get an equilibrium point where the two curves intersect. At this point, the price the consumers are willing to pay is the same as the price the producers demand. In Figure 2.3, the equilibrium price (market-clearing price) is p* and the equilibrium quantity is Q*.

Equilibrium

Figure 2.3: Equilibrium

The equilibrium point has two important properties in that it is most often (but not always) stable and self-correcting. That it is stable means that, if the market is in equilibrium there is no tendency to move away from it. That it is selfcorrecting means that, if the market is not in equilibrium then there is a tendency to move towards it.

To see more clearly what this means, suppose the price is higher than in equilibrium, e.g. that it is p2. At that price, producers are willing to supply the quantity Q1 whereas the consumers are only willing to buy the quantity Q2. Therefore, there is an excess supply of the good. To get rid of the extra units the producers are prepared to lower the price. This will push the price downwards, closer to p*. At p*, there is no excess supply and the downward push on the price ends.

Then assume, instead, that the price is lower than p*, e.g. that it is p3. At this price, the consumers demand the quantity Q3 whereas the producers are only willing to supply the quantity Q4. Consequently, there will be a shortage of the good, and the consumers will be prepared to bid up the price to get more units.

This will tend to push the price upwards, closer to p* where, again, the push will end.

How to Find the Equilibrium Point Mathematically

Supply and demand can be written as mathematical functions, and in simple examples, they are often straight lines. They could, for instance, be:

 Supply and demand can be written as mathematical functions

Here, QD is the quantity demanded, QS is the quantity supplied, and p is the price. We now want to find the price, p*, that makes QD = QS. If the left-hand sides above are equal, the right-hand sides must also be so. Therefore, substitute p* for p and set the right-hand sides equal to each other:

85+ 30p* + 185+ 20p*

To get p* alone on the left-hand side, we add 20 p* on both sides and subtract 85 from both sides. Then we have that

50p* =100.

Dividing by 50 on both sides yields the result that

p* = 2

If we then want to know the equilibrium quantity, Q*, we substitute the result we got for p* into either the supply or the demand function above. (Note that they must yield the same quantity, since p*, by definition, is the price that makes QD = QS.)

 Supply and demand can be written as mathematical functions

Consequently, we have the equilibrium price, p* = 2, and the equilibrium quantity, Q* = 145.

Price and Quantity Regulations

Many markets are, for a number of reasons, regulated. The government could for instance decide about prices that the market is not allowed to go above or below, or about maximum quantities. Such regulations will benefit certain groups of people, but often have unintended negative side effects. These are often called secondary effects.

Minimum Prices

Minimum prices (also called price floors) are often used for wages (the price of labor) and for certain types of goods such as agricultural goods. The minimum price is usually chosen above the equilibrium price, as in the opposite case it would not have any effect. (The market participants would then choose p* instead.) Consumers and producers are consequently prevented from reaching the equilibrium price p*.

Look at Figure 2.4. The effect of the minimum price is that the consumers only demand the quantity Q2 whereas the producers supply the quantity Q1. Therefore, we get an excess supply of the good.

Note that consumers and producers are allowed to buy and sell at any price above the minimum price. A price higher then pmin will however result in an even larger excess supply, so typically the minimum price is chosen.

The situation described is not an equilibrium. To see that, note that point 2 in the definition of an equilibrium (see Section 2.3) is not satisfied: Given the price pmin producers want to sell the quantity Q1, but that is not possible since the consumers only want to buy the quantity Q2.

The Effect of a Minimum Price

Figure 2.4: The Effect of a Minimum Price

Maximum Prices

Maximum prices (also called price ceilings) are in several countries used for apartment rentals. For a maximum price to have any effect, it has to be below the equilibrium price, and the effects are the opposite to those of a minimum price. In Figure 2.5, pmax is the maximum price. It causes the consumers to demand

the quantity Q1 whereas the producers only want to supply Q2, and, consequently, there is a shortage. A typical consequence of a maximum price is that the search time to find an appropriate good is increased since the supply is too small to meet the demand.

The Effect of a Maximum Price

Figure 2.5: The Effect of a Maximum Price

Quantity Regulations

The effects of quantity regulations are similar to those of price regulations. Assume for instance that there is a restriction stating that one may only import the quantity Qmax of a certain good, say Asian textiles.

The Effect of a Quantity Regulation

Figure 2.6: The Effect of a Quantity Regulation

Producers would have been willing to supply the quantity Qmax at a price of pS, whereas the consumers would have been willing to buy that quantity at a price of pD. Since the quantity is not allowed to increase, there is excess demand at all prices other than pD. When there is excess demand, consumers are likely to bid up the price, so the price that this market is likely to arrive at is pD. Note that at the price pD, producers are willing to supply a much larger quantity, Q1, but that they are prevented from doing so by the regulation. The consumers

have to pay a price that is larger than the equilibrium price (pD instead of p*) and they get fewer units of the good, so they typically are made worse off by a quantity regulation.

Back to Top